He started his career as an assistant director to Fazil. The duo of Siddique and Lal was spotted by Fazil when he saw them performing in the Cochin Kalabhavan troupe. Siddique later teamed up with Lal to create many films and was credited as Siddique-Lal. The duo has since split up, Siddique has continued with his directorial ventures, while Lal has turned to acting and producing. Siddique's films are all in the comedy genre. Siddique's films in Tamil have mostly been remakes of his Malayalam films.

His film Bodyguard in Malayalam has been remade into Tamil as Kaavalan by Siddique himself. He also remade the film into Hindi as Bodyguard; all three versions receiving tremendous response at the box-office.

The genius of Siddique is further elevated by the fact that he has never minted out a flop movie. All along his career as a director he is always a hit maker.